About Chomsky, patterns, non-codingRNAs and genomic immunity

Non-coding RNAs, like many large proteins, have a multi-domain architecture that organizes them spatially and functionally. The study of the structure-function relationship may permit exploitation of ncRNAs as new therapeutic targets in cancer and immune disorders. Dr. George Calin and his team  suggests that spectrums of “letters” (ncRNA elements) are assembled into “words” (ncRNA domains) that are further organized into “phrases” (complete ncRNA structures) with functional meaning (signaling output) through complex “sentences” (the ncRNAs interactor networks). The analogy with linguistics is not accidental- discover its meaning by attending this lecture!

About our speaker

George Calin MD, PhD

MD Anderson Cancer Center Texas, USA

Dr. George Calin, Professor in the Experimental Therapeutics and Leukemia Departments at M. D. Anderson Cancer Center in Houston, was the first to discover the link between microRNAs and human cancers, a finding considered as a milestone in microRNA research history. His research focuses on the roles of microRNAs and other non-coding RNAs in cancer initiation and progression and in immune disorders, as well as the mechanisms of cancer predisposition linked to non-codingRNAs.

He received both his M.D. and Ph.D. degrees at Carol Davila University of Medicine in Bucharest, Romania. After working cytogenetics as an undergraduate student with Dr. Dragos Stefanescu in Bucharest, he completed a cancer genomics training in Dr. Massimo Negrini’s laboratory at University of Ferrara, Italy. In 2000 he became a postdoctoral fellow at Kimmel Cancer Center in Philadelphia, PA and while working in Dr. Carlo Croce laboratory Dr. Calin had his microRNA breakthrough.

Research Gate